3lco Summary

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Inhibitor Bound to A DFG-Out structure of the Kinase Domain of CSF-1R

The structure was published by Meyers, M.J., Pelc, M., Kamtekar, S., et al., Parlow, J.J., Anderson, D.R., and Thorarensen, A., in 2010 in a paper entitled "Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.4 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Macrophage colony-stimulating factor 1 receptor. This molecule has the UniProt identifier P07333 (CSF1R_HUMAN)search. The sample contained 324 residues which is < 90% of the natural sequence. Out of 324 residues 287 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Macrophage colony-stimulating factor 1 receptor P07333 (550-919) (CSF1R_HUMAN)search Homo sapienssearch < 90% 324 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P07333 (550 - 919) Macrophage colony-stimulating factor 1 receptor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P07333) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch protein kinase activitysearch transmembrane receptor protein tyrosine kinase activitysearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class III, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch