› 3lbw

X-ray diffraction
1.65Å resolution

High resolution crystal structure of transmembrane domain of M2

Released:
DOI: 10.2210/pdb3lbw/pdb
PDB entry 3lbw coloured by chain, front view.
PDB entry 3lbw coloured by chain, side view.
PDB entry 3lbw coloured by chain, top view.
Source organism: H3N2 subtype
Primary publication:
Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus.
Acharya R, Carnevale V, Fiorin G, Levine BG, Polishchuk AL, Balannik V, Samish I, Lamb RA, Pinto LH, DeGrado WF, Klein ML
Proc Natl Acad Sci U S A 107 15075-80 (2010)
PMID: 20689043

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130718 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix protein 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 23 amino acids
Theoretical weight: 2.45 KDa
Source organism: H3N2 subtype
Expression system: Not provided
UniProt:
  • Canonical: O70632 (Residues: 25-46; Coverage: 23%)
Gene name: M

Ligands and Environments

3 bound ligands:
Ligand Z82 4 x Z82
Ligand PEG 3 x PEG
Ligand XYL 1 x XYL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: C2221
Unit cell:
a: 48.665Å b: 79.091Å c: 48.559Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.196 0.205
Expression system: Not provided

Quick links

Citations

19 review citations

Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family.
DeCoursey TE. (2013)
18 more

55 mentions without citation

Viroporins: structure and biological functions.
Nieva et al. (2012)
54 more