3lb6 Summary

pdbe.org/3lb6
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The structure of IL-13 in complex with IL-13Ralpha2

The structure was published by Lupardus, P.J., Birnbaum, M.E., and Garcia, K.C., in 2010 in a paper entitled "Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.05 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This entry contains 12 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Interleukin-13 P35225 (15-146) (IL13_HUMAN)search Homo sapienssearch 92% 132 82%
C Interleukin-13 receptor subunit alpha-2 Q14627 (1-380) (I13R2_HUMAN)search Homo sapienssearch < 90% 380 66%
B Interleukin-13 P35225 (15-146) (IL13_HUMAN)search Homo sapienssearch 92% 132 82%
D Interleukin-13 receptor subunit alpha-2 Q14627 (1-380) (I13R2_HUMAN)search Homo sapienssearch < 90% 380 75%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P35225 (15 - 146) Interleukin-13 Homo sapiens
Q14627 (1 - 380) Interleukin-13 receptor subunit alpha-2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P35225) Growth Hormone; Chain: A;search PF03487: Interleukin-13search
C Interleukin-6 receptor alpha chain, bindingsearch
B (P35225) Growth Hormone; Chain: A;search PF03487: Interleukin-13search
D Interleukin-6 receptor alpha chain, bindingsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35225) immune responsesearch cytokine receptor bindingsearch extracellular regionsearch
C (Q14627) cytokine receptor activitysearch membranesearch
B (P35225) immune responsesearch cytokine receptor bindingsearch extracellular regionsearch
D (Q14627) cytokine receptor activitysearch membranesearch

Chain InterPro annotation
A Interleukin-4/interleukin-13search Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch Interleukin-4/interleukin-13, conserved sitesearch Interleukin-13search
C Short hematopoietin receptor, family 2, conserved sitesearch Fibronectin type IIIsearch Immunoglobulin-like foldsearch Interleukin-6 receptor alpha, bindingsearch
B Interleukin-4/interleukin-13search Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch Interleukin-4/interleukin-13, conserved sitesearch Interleukin-13search
D Short hematopoietin receptor, family 2, conserved sitesearch Fibronectin type IIIsearch Immunoglobulin-like foldsearch Interleukin-6 receptor alpha, bindingsearch