Structure analysis

The structure of IL-13 in complex with IL-13Ralpha2

X-ray diffraction
3.05Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 4 distinct polypeptide molecules

Assemblies

Assembly 1
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Multimeric state: hetero dimer
Accessible surface area: 18285.32 Å2
Buried surface area: 2124.33 Å2
Dissociation area: 875.51 Å2
Dissociation energy (ΔGdiss): 4.85 kcal/mol
Dissociation entropy (TΔSdiss): 11.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152844
Assembly 2 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 20368.59 Å2
Buried surface area: 2223.61 Å2
Dissociation area: 911.87 Å2
Dissociation energy (ΔGdiss): 6.3 kcal/mol
Dissociation entropy (TΔSdiss): 11.93 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152844

Macromolecules

Chain: A
Length: 132 amino acids
Theoretical weight: 14.33 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P35225 (Residues: 15-146; Coverage: 100%)
Gene names: IL13, NC30
Pfam: Interleukin-13
InterPro:
CATH: Growth Hormone; Chain: A;

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Chain: C
Length: 380 amino acids
Theoretical weight: 44.25 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q14627 (Residues: 1-380; Coverage: 100%)
Gene names: IL13R, IL13RA2
Pfam: Interleukin-6 receptor alpha chain, binding
InterPro:
CATH: Immunoglobulins

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Chain: B
Length: 132 amino acids
Theoretical weight: 14.36 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P35225 (Residues: 15-146; Coverage: 100%)
Gene names: IL13, NC30
Pfam: Interleukin-13
InterPro:
CATH: Growth Hormone; Chain: A;

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Chain: D
Length: 380 amino acids
Theoretical weight: 44.25 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q14627 (Residues: 1-380; Coverage: 100%)
Gene names: IL13R, IL13RA2
Pfam: Interleukin-6 receptor alpha chain, binding
InterPro:
CATH: Immunoglobulins

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