› 3l9p

X-ray diffraction
1.8Å resolution

Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain

Released:
DOI: 10.2210/pdb3l9p/pdb
PDB entry 3l9p coloured by chain, front view.
PDB entry 3l9p coloured by chain, side view.
PDB entry 3l9p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.
Lee CC, Jia Y, Li N, Sun X, Ng K, Ambing E, Gao MY, Hua S, Chen C, Kim S, Michellys PY, Lesley SA, Harris JL, Spraggon G
Biochem J 430 425-37 (2010)
PMID: 20632993

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ALK tyrosine kinase receptor Chain: A
Molecule details ›
Chain: A
Length: 367 amino acids
Theoretical weight: 41.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UM73 (Residues: 1072-1410; Coverage: 21%)
Gene name: ALK
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P212121
Unit cell:
a: 52.058Å b: 56.904Å c: 103.607Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.226
Expression system: Spodoptera frugiperda

Quick links

Citations

34 review citations

Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology.
Hallberg et al. (2013)
33 more

12 mentions without citation

Anaplastic Lymphoma Kinase (ALK) Receptor Tyrosine Kinase: A Catalytic Receptor with Many Faces.
Huang H. (2018)
11 more