3l9p Summary


Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain

The structure was published by Lee, C.C., Jia, Y., Li, N., et al., Lesley, S.A., Harris, J.L., and Spraggon, G., in 2010 in a paper entitled "Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Anaplastic lymphoma kinase. This molecule has the UniProt identifier Q9UM73 (ALK_HUMAN)search. The sample contained 367 residues which is < 90% of the natural sequence. Out of 367 residues 301 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Anaplastic lymphoma kinase Q9UM73 (1072-1410) (ALK_HUMAN)search Homo sapienssearch < 90% 367 82%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9UM73 (1072 - 1410) Anaplastic lymphoma kinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (Q9UM73) membranesearch phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch signal transductionsearch protein phosphorylationsearch neuron developmentsearch activation of MAPK activitysearch ATP bindingsearch transmembrane receptor protein tyrosine kinase activitysearch protein tyrosine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch ALK tyrosine kinase receptorsearch