3l9n Summary


crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 27

The structure was published by Zeng, Q., Allen, J.G., Bourbeau, M.P., et al., Dominguez, C., Hungate, R., and Zhang, X., in 2010 in a paper entitled "Azole-based inhibitors of AKT/PKB for the treatment of cancer." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely cAMP-dependent protein kinase catalytic subunit alpha and cAMP-dependent protein kinase inhibitor alpha.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A cAMP-dependent protein kinase catalytic subunit alpha P17612 (1-351) (KAPCA_HUMAN)search Homo sapienssearch 96% 351 95%
C cAMP-dependent protein kinase inhibitor alpha P61925 (6-25) (IPKA_HUMAN)search Homo sapienssearch < 90% 20 95%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P17612 (1 - 351) cAMP-dependent protein kinase catalytic subunit alpha Homo sapiens
P61925 (6 - 25) cAMP-dependent protein kinase inhibitor alpha Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P17612) Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch
C cAMP-dependent protein kinase inhibitorsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P17612) protein phosphorylationsearch regulation of insulin secretionsearch peptidyl-serine phosphorylationsearch phosphorylationsearch calcium-mediated signaling using intracellular calcium sourcesearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of cell cycle arrestsearch gluconeogenesissearch innate immune responsesearch energy reserve metabolic processsearch small molecule metabolic processsearch fibroblast growth factor receptor signaling pathwaysearch regulation of synaptic transmissionsearch cellular response to glucose stimulussearch cell communication by electrical coupling involved in cardiac conductionsearch intracellular signal transductionsearch G2/M transition of mitotic cell cyclesearch mitotic cell cyclesearch triglyceride catabolic processsearch regulation of protein processingsearch regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionsearch cellular response to parathyroid hormone stimulussearch glucose metabolic processsearch transmembrane transportsearch regulation of protein bindingsearch activation of protein kinase A activitysearch sperm capacitationsearch cytosolic calcium ion homeostasissearch carbohydrate metabolic processsearch cellular response to glucagon stimulussearch protein autophosphorylationsearch blood coagulationsearch negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningsearch water transportsearch neural tube closuresearch mesoderm formationsearch positive regulation of protein export from nucleussearch epidermal growth factor receptor signaling pathwaysearch regulation of tight junction assemblysearch cellular response to epinephrine stimulussearch regulation of cardiac muscle contractionsearch regulation of osteoblast differentiationsearch regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of proteasomal protein catabolic processsearch regulation of heart ratesearch signal transductionsearch activation of phospholipase C activitysearch peptidyl-threonine phosphorylationsearch nucleussearch cytosolsearch mitochondrionsearch membranesearch ciliumsearch motile ciliumsearch cAMP-dependent protein kinase complexsearch cytoplasmsearch plasma membranesearch calcium channel complexsearch extracellular vesicular exosomesearch ciliary basesearch cell projectionsearch neuromuscular junctionsearch centrosomesearch protein bindingsearch protein serine/threonine kinase activitysearch transferase activitysearch cAMP-dependent protein kinase activitysearch ATP bindingsearch protein kinase activitysearch protein kinase bindingsearch kinase activitysearch nucleotide bindingsearch protein serine/threonine/tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ubiquitin protein ligase bindingsearch
C (P61925) negative regulation of protein kinase activitysearch cAMP-dependent protein kinase inhibitor activitysearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
C cAMP-dependent protein kinase inhibitorsearch