3l9j Summary


Selection of a novel highly specific TNFalpha antagonist: Insight from the crystal structure of the antagonist-TNFalpha complex

The structure was published by Byla, P., Andersen, M.H., Holtet, T.L., et al., Gad, H.H., Thogersen, H.C., and Hartmann, R., in 2010 in a paper entitled "Selection of a novel and highly specific TNF{alpha} antagonist: insight from the crystal structure of the antagonist-TNF{alpha} complex" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely TNFalpha and Tumor necrosis factor, soluble form.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
C TNFalpha P05452 (67-201) (TETN_HUMAN)search Homo sapienssearch 100% 134 97%
T Tumor necrosis factor, soluble form P01375 (85-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 149 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P05452 (67 - 201) TNFalpha Homo sapiens
P01375 (85 - 233) Tumor necrosis factor, soluble form Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
C (P05452) Mannose-Binding Protein A, subunit Asearch PF00059: Lectin C-type domainsearch
T Jelly Rollssearch TNF(Tumour Necrosis Factor) familysearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
C (P05452) carbohydrate bindingsearch
T (P01375) tumor necrosis factor receptor bindingsearch membranesearch immune responsesearch

Chain InterPro annotation
C C-type lectinsearch C-type lectin-likesearch C-type lectin foldsearch
T Tumour necrosis factor alphasearch Tumour necrosis factor domainsearch Tumour necrosis factorsearch Tumour necrosis factor-like domainsearch Tumour necrosis factor, conserved sitesearch