3l8x Summary


PDB entry 3l8x (supersedes 3cg2)

P38 alpha kinase complexed with a pyrazolo-pyrimidine based inhibitor

The structure was published by Das, J., Moquin, R.V., Pitt, S., et al., Dodd, J.H., Schieven, G.L., and Leftheris, K., in 2008 in a paper entitled "Pyrazolo-Pyrimidines: A Novel Heterocyclic Scaffold for Potent and Selective P38 Alpha Inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 366 residues which is 100% of the natural sequence. Out of 366 residues 320 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 366 89%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch nucleotide bindingsearch NFAT protein bindingsearch MAP kinase activitysearch MAP kinase kinase activitysearch protein serine/threonine kinase activitysearch kinase activitysearch transferase activitysearch innate immune responsesearch negative regulation of canonical Wnt signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch toll-like receptor signaling pathwaysearch striated muscle cell differentiationsearch p38MAPK cascadesearch DNA damage checkpointsearch positive regulation of myoblast differentiationsearch muscle cell differentiationsearch chemotaxissearch myoblast differentiation involved in skeletal muscle regenerationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch phosphorylationsearch toll-like receptor 5 signaling pathwaysearch stress-activated MAPK cascadesearch protein phosphorylationsearch cartilage condensationsearch chondrocyte differentiationsearch Ras protein signal transductionsearch intracellular signal transductionsearch cellular response to ionizing radiationsearch cellular response to DNA damage stimulussearch toll-like receptor TLR1:TLR2 signaling pathwaysearch peptidyl-serine phosphorylationsearch activation of MAPK activitysearch positive regulation of myotube differentiationsearch positive regulation of reactive oxygen species metabolic processsearch signal transduction in response to DNA damagesearch platelet activationsearch toll-like receptor 10 signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch regulation of transcription from RNA polymerase II promotersearch toll-like receptor 2 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch transcription, DNA-templatedsearch apoptotic processsearch movement of cell or subcellular componentsearch signal transductionsearch skeletal muscle tissue developmentsearch cell morphogenesissearch positive regulation of blood vessel endothelial cell migrationsearch mitochondrion organizationsearch positive regulation of myoblast fusionsearch vascular endothelial growth factor receptor signaling pathwaysearch angiogenesissearch positive regulation of erythrocyte differentiationsearch response to muramyl dipeptidesearch cell surface receptor signaling pathwaysearch response to lipopolysaccharidesearch organelle organizationsearch TRIF-dependent toll-like receptor signaling pathwaysearch stress-induced premature senescencesearch positive regulation of protein import into nucleussearch gene expressionsearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of muscle cell differentiationsearch toll-like receptor 3 signaling pathwaysearch osteoclast differentiationsearch 3'-UTR-mediated mRNA stabilizationsearch cellular response to vascular endothelial growth factor stimulussearch glucose metabolic processsearch fatty acid oxidationsearch blood coagulationsearch positive regulation of brown fat cell differentiationsearch toll-like receptor 9 signaling pathwaysearch cellular response to lipopolysaccharidesearch cytosolsearch nucleussearch nucleoplasmsearch cytoplasmsearch cellsearch spindle polesearch mitochondrionsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch