PDB entry 3l8x (supersedes 3cg2)
P38 alpha kinase complexed with a pyrazolo-pyrimidine based inhibitor
The structure was published by Das, J., Moquin, R.V., Pitt, S., et al., Dodd, J.H., Schieven, G.L., and Leftheris, K., in 2008 in a paper entitled "Pyrazolo-Pyrimidines: A Novel Heterocyclic Scaffold for Potent and Selective P38 Alpha Inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN). The sample contained 366 residues which is 100% of the natural sequence. Out of 366 residues 320 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: