3l6f Summary

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Structure of MHC class II molecule HLA-DR1 complexed with phosphopeptide MART-1

The structure was published by Li, Y., Depontieu, F.R., Sidney, J., et al., Sette, A., Topalian, S.L., and Mariuzza, R.A., in 2010 in a paper entitled "Structural Basis for the Presentation of Tumor-Associated MHC Class II-Restricted Phosphopeptides to CD4(+) T Cells." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, and Melanoma antigen recognized by T-cells 1.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HLA class II histocompatibility antigen, DR alpha chain P01903 (26-207) (DRA_HUMAN)search Homo sapienssearch < 90% 182 97%
B HLA class II histocompatibility antigen, DRB1-1 beta chain P04229 (30-221) (2B11_HUMAN)search Homo sapienssearch < 90% 193 98%
C Melanoma antigen recognized by T-cells 1 Q16655 (100-114) (MAR1_HUMAN)search Homo sapienssearch < 90% 15 100%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P01903 (26 - 207) HLA class II histocompatibility antigen, DR alpha chain Homo sapiens
P04229 (30 - 221) HLA class II histocompatibility antigen, DRB1-1 beta chain Homo sapiens
Q16655 (100 - 114) Melanoma antigen recognized by T-cells 1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
C Protein melan-Asearch

Chain ID Biological process (GO) Cellular component (GO)
A (P01903) antigen processing and presentationsearch immune responsesearch MHC class II protein complexsearch membranesearch
B (P04229) immune responsesearch antigen processing and presentationsearch membranesearch MHC class II protein complexsearch

Chain InterPro annotation
A MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
C