3l14 Summary

pdbe.org/3l14
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Human Carbonic Anhydrase II complexed with Althiazide

A publication describing this structure is not available. The depositing authors are Quirit, J.G.search; Robbins, A.search; Genis, C.search; Tu, C.search; Silverman, D.N.search; McKenna, R.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.22 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) cytoplasmsearch cytosolsearch axonsearch microvillussearch extracellular spacesearch extracellular vesicular exosomesearch membranesearch basolateral plasma membranesearch plasma membranesearch apical part of cellsearch myelin sheathsearch positive regulation of dipeptide transmembrane transportsearch bicarbonate transportsearch response to organic substancesearch regulation of intracellular pHsearch positive regulation of cellular pH reductionsearch regulation of anion transportsearch regulation of chloride transportsearch one-carbon metabolic processsearch positive regulation of osteoclast differentiationsearch kidney developmentsearch small molecule metabolic processsearch odontogenesis of dentin-containing toothsearch positive regulation of bone resorptionsearch response to zinc ionsearch angiotensin-activated signaling pathwaysearch secretionsearch response to steroid hormonesearch positive regulation of synaptic transmission, GABAergicsearch response to pHsearch response to estrogensearch morphogenesis of an epitheliumsearch carbonate dehydratase activitysearch zinc ion bindingsearch lyase activitysearch protein bindingsearch metal ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch