3ky2 Summary

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Crystal structure of Fibroblast Growth Factor Receptor 1 kinase domain

The structure was published by Bae, J.H., Boggon, T.J., Tome, F., Mandiyan, V., Lax, I., and Schlessinger, J., in 2010 in a paper entitled "Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Basic fibroblast growth factor receptor 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Basic fibroblast growth factor receptor 1 P11362 (458-765) (FGFR1_HUMAN)search Homo sapienssearch < 90% 317 96%
B Basic fibroblast growth factor receptor 1 P11362 (458-765) (FGFR1_HUMAN)search Homo sapienssearch < 90% 317 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11362 (458 - 765) Basic fibroblast growth factor receptor 1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch
Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch Fibroblast growth factor receptor 1/4search