3kul Summary

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Kinase domain of human ephrin type-A receptor 8 (EPHA8)

A publication describing this structure is not available. The depositing authors are Walker, J.R.search; Yermekbayeva, L.search; Kania, J.search; Bountra, C.search; Weigelt, J.search; Arrowsmith, C.H.search; Edwards, A.M.search; Bochkarev, A.search; Dhe-Paganon, S.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 2.15 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Ephrin type-A receptor 8.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ephrin type-A receptor 8 P29322 (602-909) (EPHA8_HUMAN)search Homo sapienssearch < 90% 325 82%
B Ephrin type-A receptor 8 P29322 (602-909) (EPHA8_HUMAN)search Homo sapienssearch < 90% 325 83%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P29322 (602 - 909) Ephrin type-A receptor 8 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch, Ephrin type-A receptor 2 transmembrane domainsearch
B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch, Ephrin type-A receptor 2 transmembrane domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (P29322) protein phosphorylationsearch transferase activity, transferring phosphorus-containing groupssearch GPI-linked ephrin receptor activitysearch ATP bindingsearch protein tyrosine kinase activitysearch protein kinase activitysearch
B (P29322) protein phosphorylationsearch ATP bindingsearch GPI-linked ephrin receptor activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch Ephrin type-A receptor 8search Ephrin receptor, transmembrane domainsearch
B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch Ephrin type-A receptor 8search Ephrin receptor, transmembrane domainsearch