3ks3 Summary

pdbe.org/3ks3
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High resolution structure of Human Carbonic Anhydrase II at 0.9 A

The structure was published by Avvaru, B.S., Kim, C.U., Sippel, K.H., et al., Agbandje-McKenna, M., Silverman, D.N., and McKenna, R., in 2010 in a paper entitled "A short, strong hydrogen bond in the active site of human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 0.9 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) morphogenesis of an epitheliumsearch secretionsearch positive regulation of cellular pH reductionsearch positive regulation of dipeptide transmembrane transportsearch response to zinc ionsearch response to steroid hormonesearch bicarbonate transportsearch regulation of anion transportsearch angiotensin-activated signaling pathwaysearch small molecule metabolic processsearch odontogenesis of dentin-containing toothsearch regulation of chloride transportsearch response to organic substancesearch one-carbon metabolic processsearch positive regulation of bone resorptionsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of osteoclast differentiationsearch response to pHsearch regulation of intracellular pHsearch response to estrogensearch kidney developmentsearch cytosolsearch extracellular vesicular exosomesearch cytoplasmsearch microvillussearch basolateral plasma membranesearch plasma membranesearch extracellular spacesearch membranesearch myelin sheathsearch axonsearch apical part of cellsearch carbonate dehydratase activitysearch lyase activitysearch metal ion bindingsearch zinc ion bindingsearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch