3krk Summary


X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of L531F murine COX-2

The structure was published by Vecchio, A.J., Simmons, D.M., and Malkowski, M.G., in 2010 in a paper entitled "Structural basis of fatty acid substrate binding to cyclooxygenase-2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Prostaglandin G/H synthase 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin G/H synthase 2 Q05769 (20-604) (PGH2_MOUSE)search Mus musculussearch 94% 591 93%
B Prostaglandin G/H synthase 2 Q05769 (20-604) (PGH2_MOUSE)search Mus musculussearch 94% 591 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (20 - 604) Prostaglandin G/H synthase 2 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q05769) Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q05769) heme bindingsearch peroxidase activitysearch prostaglandin-endoperoxide synthase activitysearch enzyme bindingsearch protein homodimerization activitysearch metal ion bindingsearch dioxygenase activitysearch lipid bindingsearch oxidoreductase activitysearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch inflammatory responsesearch cyclooxygenase pathwaysearch regulation of blood pressuresearch prostaglandin biosynthetic processsearch oxidation-reduction processsearch positive regulation of synaptic plasticitysearch cellular response to ATPsearch decidualizationsearch positive regulation of fibroblast growth factor productionsearch response to vitamin Dsearch ovulationsearch regulation of cell proliferationsearch negative regulation of synaptic transmission, dopaminergicsearch response to oxidative stresssearch embryo implantationsearch response to manganese ionsearch positive regulation of cell deathsearch negative regulation of calcium ion transportsearch learningsearch response to estradiolsearch positive regulation of brown fat cell differentiationsearch bone mineralizationsearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of smooth muscle cell proliferationsearch response to fructosesearch positive regulation vascular endothelial growth factor productionsearch negative regulation of smooth muscle contractionsearch hair cyclesearch keratinocyte differentiationsearch positive regulation of fever generationsearch positive regulation of apoptotic processsearch response to organonitrogen compoundsearch negative regulation of cell proliferationsearch fatty acid biosynthetic processsearch fatty acid metabolic processsearch response to lipopolysaccharidesearch response to cytokinesearch lipid metabolic processsearch positive regulation of smooth muscle contractionsearch positive regulation of synaptic transmission, glutamatergicsearch response to fatty acidsearch sensory perception of painsearch response to tumor necrosis factorsearch cellular response to mechanical stimulussearch positive regulation of cell migration involved in sprouting angiogenesissearch response to radiationsearch positive regulation of transforming growth factor beta productionsearch response to glucocorticoidsearch response to organic cyclic compoundsearch cellular response to hypoxiasearch response to drugsearch response to lithium ionsearch angiogenesissearch prostaglandin metabolic processsearch memorysearch cellular response to UVsearch brown fat cell differentiationsearch positive regulation of platelet-derived growth factor productionsearch maintenance of blood-brain barriersearch negative regulation of cell cyclesearch response to organic substancesearch positive regulation of NF-kappaB import into nucleussearch positive regulation of vasoconstrictionsearch neuron projectionsearch protein complexsearch intracellular membrane-bounded organellesearch cytoplasmsearch membranesearch endoplasmic reticulumsearch

Chain InterPro annotation
A, B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search