3krk Summary


X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of L531F murine COX-2

The structure was published by Vecchio, A.J., Simmons, D.M., and Malkowski, M.G., in 2010 in a paper entitled "Structural basis of fatty acid substrate binding to cyclooxygenase-2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Prostaglandin G/H synthase 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin G/H synthase 2 Q05769 (20-604) (PGH2_MOUSE)search Mus musculussearch 94% 591 93%
B Prostaglandin G/H synthase 2 Q05769 (20-604) (PGH2_MOUSE)search Mus musculussearch 94% 591 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (20 - 604) Prostaglandin G/H synthase 2 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q05769) Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q05769) regulation of cell proliferationsearch positive regulation of brown fat cell differentiationsearch regulation of blood pressuresearch oxidation-reduction processsearch bone mineralizationsearch cellular response to hypoxiasearch embryo implantationsearch positive regulation of transforming growth factor beta productionsearch fatty acid metabolic processsearch response to glucocorticoidsearch response to cytokinesearch response to tumor necrosis factorsearch cyclooxygenase pathwaysearch response to fatty acidsearch cellular response to ATPsearch angiogenesissearch positive regulation of vasoconstrictionsearch lipid metabolic processsearch positive regulation of synaptic plasticitysearch negative regulation of synaptic transmission, dopaminergicsearch prostaglandin biosynthetic processsearch positive regulation of cell deathsearch prostaglandin metabolic processsearch keratinocyte differentiationsearch positive regulation of fever generationsearch positive regulation of platelet-derived growth factor productionsearch response to oxidative stresssearch response to lipopolysaccharidesearch positive regulation of fibroblast growth factor productionsearch response to organic cyclic compoundsearch positive regulation of NF-kappaB import into nucleussearch response to radiationsearch ovulationsearch positive regulation of smooth muscle cell proliferationsearch negative regulation of calcium ion transportsearch cellular response to UVsearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of cell proliferationsearch hair cyclesearch learningsearch fatty acid biosynthetic processsearch positive regulation of synaptic transmission, glutamatergicsearch sensory perception of painsearch positive regulation of apoptotic processsearch memorysearch positive regulation of smooth muscle contractionsearch response to drugsearch negative regulation of cell cyclesearch response to fructosesearch response to estradiolsearch negative regulation of smooth muscle contractionsearch decidualizationsearch positive regulation of cell migration involved in sprouting angiogenesissearch positive regulation vascular endothelial growth factor productionsearch response to lithium ionsearch maintenance of blood-brain barriersearch response to vitamin Dsearch response to organonitrogen compoundsearch inflammatory responsesearch cellular response to mechanical stimulussearch brown fat cell differentiationsearch negative regulation of cell proliferationsearch response to manganese ionsearch response to organic substancesearch oxidoreductase activitysearch prostaglandin-endoperoxide synthase activitysearch enzyme bindingsearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch protein homodimerization activitysearch lipid bindingsearch metal ion bindingsearch peroxidase activitysearch heme bindingsearch dioxygenase activitysearch endoplasmic reticulum membranesearch protein complexsearch neuron projectionsearch endoplasmic reticulumsearch organelle membranesearch membranesearch intracellular membrane-bounded organellesearch cytoplasmsearch caveolasearch

Chain InterPro annotation
A, B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search