EC 1.14.99.1: Prostaglandin-endoperoxide synthase
Reaction catalysed:
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O
Systematic name:
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase
Alternative Name(s):
- (PG)H synthase
- Fatty acid cyclooxygenase
- PG synthetase
- Prostaglandin G/H synthase
- Prostaglandin endoperoxide synthetase
- Prostaglandin synthase
- Prostaglandin synthetase
GO terms
Biochemical function:
- dioxygenase activity
- metal ion binding
- protein homodimerization activity
- heme binding
- enzyme binding
- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
- oxidoreductase activity
- protein binding
- prostaglandin-endoperoxide synthase activity
- peroxidase activity
Biological process:
- response to angiotensin
- cellular response to homocysteine
- negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
- regulation of neuroinflammatory response
- cellular oxidant detoxification
- positive regulation of platelet-derived growth factor production
- positive regulation of brown fat cell differentiation
- positive regulation of fibroblast growth factor production
- positive regulation of cell migration involved in sprouting angiogenesis
- positive regulation of transforming growth factor beta production
- cellular response to fluid shear stress
- cellular response to non-ionic osmotic stress
- cellular response to hypoxia
- cellular response to organonitrogen compound
- cellular response to ATP
- cellular response to lead ion
- cellular response to mechanical stimulus
- response to fatty acid
- positive regulation of synaptic transmission, glutamatergic
- negative regulation of calcium ion transport
- response to glucocorticoid
- brown fat cell differentiation
- positive regulation of smooth muscle cell proliferation
- decidualization
- positive regulation of smooth muscle contraction
- negative regulation of smooth muscle contraction
- positive regulation of vasoconstriction
- negative regulation of cell cycle
- positive regulation of nitric oxide biosynthetic process
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- hair cycle
- positive regulation of protein import into nucleus
- regulation of cell population proliferation
- maintenance of blood-brain barrier
- response to tumor necrosis factor
- cellular response to heat
- response to cytokine
- response to vitamin D
- positive regulation of peptidyl-serine phosphorylation
- response to lipopolysaccharide
- response to estradiol
- prostaglandin secretion
- negative regulation of synaptic transmission, dopaminergic
- positive regulation of synaptic plasticity
- positive regulation of fever generation
- positive regulation of prostaglandin biosynthetic process
- bone mineralization
- keratinocyte differentiation
- cyclooxygenase pathway
- response to organic cyclic compound
- positive regulation of vascular endothelial growth factor production
- response to organonitrogen compound
- response to manganese ion
- response to organic substance
- response to fructose
- response to nematode
- response to xenobiotic stimulus
- negative regulation of cell population proliferation
- positive regulation of cell population proliferation
- regulation of blood pressure
- memory
- learning
- embryo implantation
- response to oxidative stress
- prostaglandin metabolic process
- fatty acid biosynthetic process
- fatty acid metabolic process
- lipid metabolic process
- angiogenesis
- prostaglandin biosynthetic process
Protein families (Pfam)
InterPro annotations
CATH domains
