3kqt Summary


Crystal Structure of hPNMT in Complex AdoHcy and 2-Amino-1-methylbenzimidazole

The structure was published by Drinkwater, N., Vu, H., Lovell, K.M., et al., McLeish, M.J., Grunewald, G.L., and Martin, J.L., in 2010 in a paper entitled "Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.399 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Phenylethanolamine N-methyltransferase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Phenylethanolamine N-methyltransferase P11086 (1-282) (PNMT_HUMAN)search Homo sapienssearch 100% 289 92%
B Phenylethanolamine N-methyltransferase P11086 (1-282) (PNMT_HUMAN)search Homo sapienssearch 100% 289 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11086 (1 - 282) Phenylethanolamine N-methyltransferase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P11086) Vaccinia Virus protein VP39search PF01234: NNMT/PNMT/TEMT familysearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P11086) methyltransferase activitysearch phenylethanolamine N-methyltransferase activitysearch transferase activitysearch catecholamine biosynthetic processsearch cellular nitrogen compound metabolic processsearch small molecule metabolic processsearch epinephrine biosynthetic processsearch methylationsearch cytosolsearch

Chain InterPro annotation
A, B Methyltransferase, NNMT/PNMT/TEMTsearch Methyltransferase NNMT/PNMT/TEMT, conserved sitesearch S-adenosyl-L-methionine-dependent methyltransferase-likesearch