3kq7 Summary


Structure of human p38alpha with N-[4-methyl-3-(6-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}pyridine-3-amido)phenyl]-2-(morpholin-4-yl)pyridine-4-carboxamide

The structure was published by Cheng, R.K.Y., Barker, J., and Whittaker, M., in in a paper entitled "Structure of human p38alpha with N-[4-methyl-3-(6-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}pyridine-3-amido)phenyl]-2-(morpholin-4-yl)pyridine-4-carboxamide" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase p38 alpha. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 380 residues which is 100% of the natural sequence. Out of 380 residues 348 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase p38 alpha Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 380 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase p38 alpha Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch MAP kinase activitysearch protein kinase activitysearch protein bindingsearch NFAT protein bindingsearch protein serine/threonine kinase activitysearch kinase activitysearch nucleotide bindingsearch MAP kinase kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch transferase activitysearch protein phosphorylationsearch activation of MAPK activitysearch positive regulation of blood vessel endothelial cell migrationsearch apoptotic processsearch positive regulation of muscle cell differentiationsearch platelet activationsearch regulation of sequence-specific DNA binding transcription factor activitysearch cellular response to lipopolysaccharidesearch MyD88-dependent toll-like receptor signaling pathwaysearch Ras protein signal transductionsearch signal transduction in response to DNA damagesearch p38MAPK cascadesearch toll-like receptor 5 signaling pathwaysearch positive regulation of erythrocyte differentiationsearch striated muscle cell differentiationsearch chemotaxissearch toll-like receptor 3 signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch peptidyl-serine phosphorylationsearch regulation of transcription, DNA-templatedsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch stress-activated MAPK cascadesearch toll-like receptor signaling pathwaysearch blood coagulationsearch osteoclast differentiationsearch gene expressionsearch RNA metabolic processsearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch cartilage condensationsearch cell surface receptor signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch cellular response to ionizing radiationsearch cell morphogenesissearch toll-like receptor TLR1:TLR2 signaling pathwaysearch positive regulation of protein import into nucleussearch positive regulation of reactive oxygen species metabolic processsearch intracellular signal transductionsearch neurotrophin TRK receptor signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of myotube differentiationsearch skeletal muscle tissue developmentsearch regulation of transcription from RNA polymerase II promotersearch vascular endothelial growth factor receptor signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch stress-induced premature senescencesearch DNA damage checkpointsearch mRNA metabolic processsearch transcription, DNA-templatedsearch signal transductionsearch MAPK cascadesearch angiogenesissearch negative regulation of canonical Wnt signaling pathwaysearch cellular component movementsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch glucose metabolic processsearch toll-like receptor 9 signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch cellular response to DNA damage stimulussearch TRIF-dependent toll-like receptor signaling pathwaysearch response to stresssearch fatty acid oxidationsearch chondrocyte differentiationsearch innate immune responsesearch positive regulation of myoblast fusionsearch muscle cell differentiationsearch response to lipopolysaccharidesearch positive regulation of myoblast differentiationsearch response to muramyl dipeptidesearch phosphorylationsearch nucleoplasmsearch cytoplasmsearch cytosolsearch spindle polesearch cellsearch nucleussearch mitochondrionsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch