3kmz Summary

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Crystal structure of RARalpha ligand binding domain in complex with the inverse agonist BMS493 and a corepressor fragment

The structure was published by le Maire, A., Teyssier, C., Erb, C., et al., Royer, C.A., Germain, P., and Bourguet, W., in 2010 in a paper entitled "A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Retinoic acid receptor alpha and Nuclear receptor corepressor 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
B Retinoic acid receptor alpha P10276 (176-421) (RARA_HUMAN)search Homo sapienssearch < 90% 266 83%
A Retinoic acid receptor alpha P10276 (176-421) (RARA_HUMAN)search Homo sapienssearch < 90% 266 83%
C Nuclear receptor corepressor 1 O75376 (2047-2065) (NCOR1_HUMAN)search Homo sapienssearch < 90% 19 100%
D Nuclear receptor corepressor 1 O75376 (2047-2065) (NCOR1_HUMAN)search Homo sapienssearch < 90% 19 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P10276 (176 - 421) Retinoic acid receptor alpha Homo sapiens
O75376 (2047 - 2065) Nuclear receptor corepressor 1

Chain Structural classification (CATH) Sequence family (Pfam)
B, A Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
C, D

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
B, A (P10276) steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch retinoic acid receptor activitysearch DNA bindingsearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch retinoic acid receptor signaling pathwaysearch nucleussearch

Chain InterPro annotation
B, A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Retinoic acid receptorsearch Nuclear hormone receptor, ligand-bindingsearch
C, D