› 3kmg

X-ray diffraction
2.1Å resolution

The X-ray Crystal Structure of PPAR-gamma in Complex with an Indole Derivative Modulator, GSK538, and an SRC-1 Peptide

Released:
DOI: 10.2210/pdb3kmg/pdb
PDB entry 3kmg coloured by chain, front view.
PDB entry 3kmg coloured by chain, side view.
PDB entry 3kmg coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Gampe R

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153371 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peroxisome proliferator-activated receptor gamma Chains: A, D
Molecule details ›
Chains: A, D
Length: 272 amino acids
Theoretical weight: 31.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 234-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Steroid Receptor Coactivator-1 Chains: B, E
Molecule details ›
Chains: B, E
Length: 27 amino acids
Theoretical weight: 2.83 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand 538 2 x 538
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 83.335Å b: 84.158Å c: 96.425Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.198 0.23
Expression systems:
  • Escherichia coli
  • Not provided

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