3kl8 Summary

pdbe.org/3kl8
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CaMKIINtide Inhibitor Complex

The structure was published by Chao, L.H., Pellicena, P., Deindl, S., Barclay, L.A., Schulman, H., and Kuriyan, J., in 2010 in a paper entitled "Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.372 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Calcium/calmodulin dependent protein kinase II and Calcium/calmodulin-dependent protein kinase II inhibitor 1.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Calcium/calmodulin dependent protein kinase II O62305 (5-273) (KCC2D_CAEEL)search Caenorhabditis eleganssearch < 90% 269 96%
C Calcium/calmodulin dependent protein kinase II O62305 (5-273) (KCC2D_CAEEL)search Caenorhabditis eleganssearch < 90% 269 96%
E Calcium/calmodulin dependent protein kinase II O62305 (5-273) (KCC2D_CAEEL)search Caenorhabditis eleganssearch < 90% 269 96%
G Calcium/calmodulin dependent protein kinase II O62305 (5-273) (KCC2D_CAEEL)search Caenorhabditis eleganssearch < 90% 269 96%
I Calcium/calmodulin dependent protein kinase II O62305 (5-273) (KCC2D_CAEEL)search Caenorhabditis eleganssearch < 90% 269 96%
B Calcium/calmodulin-dependent protein kinase II inhibitor 1 Q9JI15 (42-58) (CK2N1_RAT)search Rattus norvegicussearch < 90% 18 100%
D Calcium/calmodulin-dependent protein kinase II inhibitor 1 Q9JI15 (42-58) (CK2N1_RAT)search Rattus norvegicussearch < 90% 18 100%
F Calcium/calmodulin-dependent protein kinase II inhibitor 1 Q9JI15 (42-58) (CK2N1_RAT)search Rattus norvegicussearch < 90% 18 100%
H Calcium/calmodulin-dependent protein kinase II inhibitor 1 Q9JI15 (42-58) (CK2N1_RAT)search Rattus norvegicussearch < 90% 18 100%
J Calcium/calmodulin-dependent protein kinase II inhibitor 1 Q9JI15 (42-58) (CK2N1_RAT)search Rattus norvegicussearch < 90% 18 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
O62305 (5 - 273) Calcium/calmodulin dependent protein kinase II Caenorhabditis elegans
Q9JI15 (42 - 58) Calcium/calmodulin-dependent protein kinase II inhibitor 1 Rattus norvegicus

Chain Structural classification (CATH) Sequence family (Pfam)
A, C, E, G, I Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch
B, D, F, H, J Calcium/calmodulin-dependent protein kinase II inhibitorsearch

Chain ID Molecular function (GO) Biological process (GO)
A, C, E, G, I (O62305) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch
B, D, F, H, J (Q9JI15) protein kinase inhibitor activitysearch

Chain InterPro annotation
A, C, E, G, I Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Calcium/calmodulin-dependent/calcium-dependent protein kinasesearch
B, D, F, H, J Calcium/calmodulin-dependent protein kinase II inhibitorsearch