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CaMKIINtide Inhibitor Complex

X-ray diffraction
3.372Å resolution
PDB entry 3kl8 coloured by chain, front view.
PDB entry 3kl8 coloured by chain, side view.
PDB entry 3kl8 coloured by chain, top view.
Source organisms:
Assemblies composition:
hetero dimer (preferred)
monomeric
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Calcium/calmodulin-dependent protein kinase type II and Calcium/calmodulin-dependent protein kinase II inhibitor 1
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Multimeric state: hetero dimer
Accessible surface area: 13614.11 Å2
Buried surface area: 2038.99 Å2
Dissociation area: 1,019.5 Å2
Dissociation energy (ΔGdiss): 7.07 kcal/mol
Dissociation entropy (TΔSdiss): 8.86 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130253
Assembly 2 (preferred)
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Assembly Name: Calcium/calmodulin-dependent protein kinase type II and Calcium/calmodulin-dependent protein kinase II inhibitor 1
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Multimeric state: hetero dimer
Accessible surface area: 13275.36 Å2
Buried surface area: 2160.24 Å2
Dissociation area: 1,080.12 Å2
Dissociation energy (ΔGdiss): 7.4 kcal/mol
Dissociation entropy (TΔSdiss): 9.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130253
Assembly 3
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Assembly Name: Calcium/calmodulin-dependent protein kinase type II and Calcium/calmodulin-dependent protein kinase II inhibitor 1
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Multimeric state: hetero dimer
Accessible surface area: 13455.46 Å2
Buried surface area: 2099.03 Å2
Dissociation area: 1,049.51 Å2
Dissociation energy (ΔGdiss): 7.7 kcal/mol
Dissociation entropy (TΔSdiss): 9.06 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130253
Assembly 4
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Assembly Name: Calcium/calmodulin-dependent protein kinase type II and Calcium/calmodulin-dependent protein kinase II inhibitor 1
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Multimeric state: hetero dimer
Accessible surface area: 13522.73 Å2
Buried surface area: 1966.58 Å2
Dissociation area: 983.29 Å2
Dissociation energy (ΔGdiss): 8.82 kcal/mol
Dissociation entropy (TΔSdiss): 8.98 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130253
Assembly 5
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Assembly Name: Calcium/calmodulin-dependent protein kinase type II and Calcium/calmodulin-dependent protein kinase II inhibitor 1
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Multimeric state: hetero dimer
Accessible surface area: 13491.6 Å2
Buried surface area: 2119.7 Å2
Dissociation area: 1,059.85 Å2
Dissociation energy (ΔGdiss): 6.85 kcal/mol
Dissociation entropy (TΔSdiss): 9.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-130253
Assembly 6
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Assembly Name: Calcium/calmodulin-dependent protein kinase II inhibitor 1
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Multimeric state: monomeric
Accessible surface area: 2545.13 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-219665
Assembly 7
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Assembly Name: Calcium/calmodulin-dependent protein kinase II inhibitor 1
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Multimeric state: monomeric
Accessible surface area: 2358.78 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-219665
Assembly 8
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Assembly Name: Calcium/calmodulin-dependent protein kinase II inhibitor 1
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Multimeric state: monomeric
Accessible surface area: 2423.05 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-219665

Macromolecules

Calcium/calmodulin-dependent protein kinase type II
Chains: A, C, E, G, I
Length: 269 amino acids
Theoretical weight: 30.45 KDa
Source organism: Caenorhabditis elegans
Expression system: Escherichia coli
UniProt:
  • Canonical: O62305 (Residues: 5-273; Coverage: 37%)
Gene names: K11E8.1, unc-43
Pfam: Protein kinase domain
InterPro:
CATH:
Calcium/calmodulin-dependent protein kinase type II in PDB entry 3kl8, assembly 2, front view.
Calcium/calmodulin-dependent protein kinase type II in PDB entry 3kl8, assembly 2, side view.
Calcium/calmodulin-dependent protein kinase type II in PDB entry 3kl8, assembly 2, top view.
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Calcium/calmodulin-dependent protein kinase II inhibitor 1
Chains: B, D, F, H, J
Length: 18 amino acids
Theoretical weight: 2.01 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9JI15 (Residues: 42-58; Coverage: 22%)
Gene name: Camk2n1
InterPro: Calcium/calmodulin-dependent protein kinase II inhibitor
Calcium/calmodulin-dependent protein kinase II inhibitor 1 in PDB entry 3kl8, assembly 2, front view.
Calcium/calmodulin-dependent protein kinase II inhibitor 1 in PDB entry 3kl8, assembly 2, side view.
Calcium/calmodulin-dependent protein kinase II inhibitor 1 in PDB entry 3kl8, assembly 2, top view.
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