3kkv Summary


Structure of PKA with a protein Kinase B-selective inhibitor.

A publication describing this structure is not available. The depositing authors are Elkins, P.A.search; Concha, N.O.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely cAMP-dependent protein kinase catalytic subunit alpha and PKI kinase inhibitor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A cAMP-dependent protein kinase catalytic subunit alpha P00517 (2-351) (KAPCA_BOVIN)search Bos taurussearch 96% 350 96%
I PKI kinase inhibitor Not available
Synthetic Not available 20 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00517 (2 - 351) cAMP-dependent protein kinase catalytic subunit alpha Bos taurus

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00517) Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00517) protein kinase activitysearch ATP bindingsearch protein serine/threonine/tyrosine kinase activitysearch transferase activitysearch protein kinase A regulatory subunit bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch cAMP-dependent protein kinase activitysearch ubiquitin protein ligase bindingsearch nucleotide bindingsearch protein bindingsearch protein kinase bindingsearch kinase activitysearch nucleussearch mitochondrionsearch AMP-activated protein kinase complexsearch plasma membranesearch membranesearch cytoplasmsearch neuromuscular junctionsearch ciliary basesearch centrosomesearch extracellular vesicular exosomesearch sperm midpiecesearch protein phosphorylationsearch regulation of synaptic transmissionsearch neural tube closuresearch peptidyl-serine phosphorylationsearch peptidyl-threonine phosphorylationsearch regulation of osteoblast differentiationsearch regulation of protein processingsearch mesoderm formationsearch regulation of tight junction assemblysearch regulation of proteasomal protein catabolic processsearch negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningsearch cellular response to parathyroid hormone stimulussearch protein autophosphorylationsearch positive regulation of protein export from nucleussearch cellular response to glucose stimulussearch phosphorylationsearch sperm capacitationsearch positive regulation of cell cycle arrestsearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
I cAMP-dependent protein kinase inhibitorsearch