3kka Summary

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Co-crystal structure of the sam domains of EPHA1 AND EPHA2

A publication describing this structure is not available. The depositing authors are Walker, J.R.search; Yermekbayeva, L.search; Butler-Cole, C.search; Weigelt, J.search; Bountra, C.search; Arrowsmith, C.H.search; Edwards, A.M.search; Bochkarev, A.search; Dhe-Paganon, S.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely EPHRIN TYPE-A RECEPTOR 1 and EPHRIN TYPE-A RECEPTOR 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A EPHRIN TYPE-A RECEPTOR 1 P21709 (911-974) (EPHA1_HUMAN)search Homo sapienssearch < 90% 82 78%
B EPHRIN TYPE-A RECEPTOR 1 P21709 (911-974) (EPHA1_HUMAN)search Homo sapienssearch < 90% 82 78%
C EPHRIN TYPE-A RECEPTOR 2 P29317 (903-971) (EPHA2_HUMAN)search Homo sapienssearch < 90% 86 79%
D EPHRIN TYPE-A RECEPTOR 2 P29317 (903-971) (EPHA2_HUMAN)search Homo sapienssearch < 90% 86 79%
E EPHRIN TYPE-A RECEPTOR 2 P29317 (903-971) (EPHA2_HUMAN)search Homo sapienssearch < 90% 86 79%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P21709 (911 - 974) EPHRIN TYPE-A RECEPTOR 1 Homo sapiens
P29317 (903 - 971) EPHRIN TYPE-A RECEPTOR 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Transcription Factor, Ets-1search SAM domain (Sterile alpha motif)search
C, D, E Transcription Factor, Ets-1search SAM domain (Sterile alpha motif)search
Chain InterPro annotation
A, B Sterile alpha motif domainsearch Sterile alpha motif/pointed domainsearch Sterile alpha motif, type 1search
C, D, E Sterile alpha motif domainsearch Sterile alpha motif/pointed domainsearch Sterile alpha motif, type 1search