3kig Summary


Mutant carbonic anhydrase II in complex with an azide and an alkyne

The structure was published by Schulze Wischeler, J., Sun, D., Sandner, N.U., et al., Heine, A., Koert, U., and Klebe, G., in 2011 in a paper entitled "Stereo- and Regioselective Azide/Alkyne Cycloadditions in Carbonic Anhydrase II via Tethering, Monitored by Crystallography and Mass Spectrometry." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.39 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 265 residues which is 100% of the natural sequence. Out of 265 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 96% 265 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch metal ion bindingsearch protein bindingsearch lyase activitysearch arylesterase activitysearch positive regulation of cellular pH reductionsearch regulation of intracellular pHsearch bicarbonate transportsearch positive regulation of dipeptide transmembrane transportsearch angiotensin-activated signaling pathwaysearch small molecule metabolic processsearch odontogenesis of dentin-containing toothsearch regulation of anion transportsearch kidney developmentsearch response to steroid hormonesearch one-carbon metabolic processsearch positive regulation of osteoclast differentiationsearch response to zinc ionsearch positive regulation of bone resorptionsearch positive regulation of synaptic transmission, GABAergicsearch response to organic substancesearch response to pHsearch secretionsearch response to estrogensearch regulation of chloride transportsearch morphogenesis of an epitheliumsearch cellular response to fluid shear stresssearch cytosolsearch membranesearch cytoplasmsearch plasma membranesearch basolateral plasma membranesearch myelin sheathsearch microvillussearch axonsearch extracellular exosomesearch apical part of cellsearch extracellular spacesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch