3kga Summary


Crystal structure of MAPKAP kinase 2 (MK2) complexed with a potent 3-aminopyrazole ATP site inhibitor

The structure was published by Velcicky, J., Feifel, R., Hawtin, S., et al., Revesz, L., Scheufler, C., and Schlapbach, A., in 2010 in a paper entitled "Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.55 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of MAP kinase-activated protein kinase 2. This molecule has the UniProt identifier P49137 (MAPK2_HUMAN)search. The sample contained 299 residues which is < 90% of the natural sequence. Out of 299 residues 284 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MAP kinase-activated protein kinase 2 P49137 (47-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 299 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49137 (47 - 364) MAP kinase-activated protein kinase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P49137) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P49137) protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch