Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic
The structure was published by DeLorbe, J.E., Clements, J.H., Teresk, M.G., et al., Plake, H.R., Millspaugh, L.E., and Martin, S.F., in 2009 in a paper entitled "Thermodynamic and structural effects of conformational constraints in protein-ligand interactions. Entropic paradoxy associated with ligand preorganization." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.02 Å and deposited in 2009.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Growth factor receptor-bound protein 2. This molecule has the UniProt identifier P62993 (GRB2_HUMAN). The sample contained 117 residues which is < 90% of the natural sequence. Out of 117 residues 100 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: