3kfj Summary


Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic

The structure was published by DeLorbe, J.E., Clements, J.H., Teresk, M.G., et al., Plake, H.R., Millspaugh, L.E., and Martin, S.F., in 2009 in a paper entitled "Thermodynamic and structural effects of conformational constraints in protein-ligand interactions. Entropic paradoxy associated with ligand preorganization." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.02 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Growth factor receptor-bound protein 2. This molecule has the UniProt identifier P62993 (GRB2_HUMAN)search. The sample contained 117 residues which is < 90% of the natural sequence. Out of 117 residues 100 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Growth factor receptor-bound protein 2 P62993 (53-163) (GRB2_HUMAN)search Homo sapienssearch 100% 117 85%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62993 (53 - 163) Growth factor receptor-bound protein 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P62993) SHC Adaptor Proteinsearch PF00017: SH2 domainsearch, PF00018: SH3 domainsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P62993) membranesearch SH3/SH2 adaptor activitysearch Ras protein signal transductionsearch

Chain InterPro annotation
A SH2 domainsearch Growth factor receptor-bound protein 2search