3kf7 Summary


Crystal Structure of Human p38alpha Complexed With a Triazolopyrimidine compound

The structure was published by Jerome, K.D., Rucker, P.V., Xing, L., et al., Letavic, M.A., Braganza, J.F., and McClure, K.F., in 2010 in a paper entitled "Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 336 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch protein kinase activitysearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein bindingsearch NFAT protein bindingsearch kinase activitysearch MAP kinase kinase activitysearch nucleotide bindingsearch transferase activitysearch protein phosphorylationsearch MyD88-independent toll-like receptor signaling pathwaysearch response to lipopolysaccharidesearch cellular response to vascular endothelial growth factor stimulussearch cellular response to DNA damage stimulussearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of myoblast fusionsearch cellular response to lipopolysaccharidesearch platelet activationsearch phosphorylationsearch innate immune responsesearch positive regulation of reactive oxygen species metabolic processsearch cellular response to ionizing radiationsearch stress-induced premature senescencesearch toll-like receptor 4 signaling pathwaysearch osteoclast differentiationsearch chondrocyte differentiationsearch toll-like receptor signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch MAPK cascadesearch Ras protein signal transductionsearch positive regulation of myotube differentiationsearch toll-like receptor 2 signaling pathwaysearch glucose metabolic processsearch lipopolysaccharide-mediated signaling pathwaysearch positive regulation of protein import into nucleussearch cartilage condensationsearch p38MAPK cascadesearch toll-like receptor 3 signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch fatty acid oxidationsearch peptidyl-serine phosphorylationsearch positive regulation of blood vessel endothelial cell migrationsearch regulation of transcription, DNA-templatedsearch response to stresssearch response to muramyl dipeptidesearch activation of MAPK activitysearch skeletal muscle tissue developmentsearch chemotaxissearch positive regulation of transcription from RNA polymerase II promotersearch cell surface receptor signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch toll-like receptor TLR6:TLR2 signaling pathwaysearch positive regulation of erythrocyte differentiationsearch mRNA metabolic processsearch transcription, DNA-templatedsearch RNA metabolic processsearch cell morphogenesissearch neurotrophin TRK receptor signaling pathwaysearch signal transductionsearch blood coagulationsearch gene expressionsearch positive regulation of muscle cell differentiationsearch DNA damage checkpointsearch signal transduction in response to DNA damagesearch TRIF-dependent toll-like receptor signaling pathwaysearch angiogenesissearch negative regulation of canonical Wnt signaling pathwaysearch positive regulation of myoblast differentiationsearch muscle cell differentiationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch apoptotic processsearch 3'-UTR-mediated mRNA stabilizationsearch toll-like receptor 10 signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch striated muscle cell differentiationsearch stress-activated MAPK cascadesearch cellular component movementsearch vascular endothelial growth factor receptor signaling pathwaysearch intracellular signal transductionsearch nucleussearch nucleoplasmsearch cytosolsearch cytoplasmsearch mitochondrionsearch spindle polesearch cellsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch