Crystal Structure of Human p38alpha Complexed With a Triazolopyrimidine compound
The structure was published by Jerome, K.D., Rucker, P.V., Xing, L., et al., Letavic, M.A., Braganza, J.F., and McClure, K.F., in 2010 in a paper entitled "Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2009.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN). The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 336 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: