› 3kex

X-ray diffraction
2.8Å resolution

Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (HER3)

Released:
DOI: 10.2210/pdb3kex/pdb
PDB entry 3kex coloured by chain, front view.
PDB entry 3kex coloured by chain, side view.
PDB entry 3kex coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.
Jura N, Shan Y, Cao X, Shaw DE, Kuriyan J
Proc Natl Acad Sci U S A 106 21608-13 (2009)
PMID: 20007378

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149457 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor tyrosine-protein kinase erbB-3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 325 amino acids
Theoretical weight: 36.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P21860 (Residues: 698-1019; Coverage: 24%)
Gene names: ERBB3, HER3
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ANP 2 x ANP
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: C2
Unit cell:
a: 194.164Å b: 47.637Å c: 81.281Å
α: 90° β: 108.04° γ: 90°
R-values:
R R work R free
0.243 0.241 0.283
Expression system: Spodoptera frugiperda

Quick links

Citations

61 review citations

The ERBB network: at last, cancer therapy meets systems biology.
Yarden et al. (2012)
60 more

27 mentions without citation

Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.
Jura et al. (2011)
26 more