3ke0 Summary


Crystal structure of N370S Glucocerebrosidase at acidic pH.

A publication describing this structure is not available. The depositing authors are Wei, R.R.search; Boucher, S.search; Pan, C.Q.search; Edmunds, T.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glucosylceramidase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucosylceramidase P04062 (40-536) (GLCM_HUMAN)search Homo sapienssearch 96% 497 100%
B Glucosylceramidase P04062 (40-536) (GLCM_HUMAN)search Homo sapienssearch 96% 497 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04062 (40 - 536) Glucosylceramidase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P04062) Glycosidasessearch, Golgi alpha-mannosidase IIsearch PF02055: O-Glycosyl hydrolase family 30search

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P04062) carbohydrate metabolic processsearch response to estrogensearch lipid metabolic processsearch negative regulation of MAP kinase activitysearch negative regulation of interleukin-6 productionsearch response to glucocorticoidsearch sphingolipid metabolic processsearch cell deathsearch glucosylceramide catabolic processsearch response to pHsearch negative regulation of inflammatory responsesearch termination of signal transductionsearch ceramide biosynthetic processsearch small molecule metabolic processsearch response to testosteronesearch regulation of water loss via skinsearch sphingosine biosynthetic processsearch skin morphogenesissearch positive regulation of protein dephosphorylationsearch cellular response to tumor necrosis factorsearch glycosphingolipid metabolic processsearch metabolic processsearch response to thyroid hormonesearch glucosylceramidase activitysearch receptor bindingsearch protein bindingsearch hydrolase activitysearch hydrolase activity, acting on glycosyl bondssearch lysosomesearch lysosomal membranesearch membranesearch lysosomal lumensearch extracellular vesicular exosomesearch

Chain InterPro annotation
A, B Glycoside hydrolase, family 30search Glycosyl hydrolase, family 13, all-betasearch Glycoside hydrolase, catalytic domainsearch Glycoside hydrolase superfamilysearch