3kb7 Summary

pdbe.org/3kb7
spacer

Crystal structure of Polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor

The structure was published by Beria, I., Ballinari, D., Bertrand, J.A., et al., Storici, P., Volpi, D., and Valsasina, B., in 2010 in a paper entitled "Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Serine/threonine-protein kinase PLK1. This molecule has the UniProt identifier P53350 (PLK1_HUMAN)search. The sample contained 311 residues which is < 90% of the natural sequence. Out of 311 residues 290 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase PLK1 P53350 (36-345) (PLK1_HUMAN)search Homo sapienssearch < 90% 311 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P53350 (36 - 345) Serine/threonine-protein kinase PLK1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P53350) transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch