Crystal structure of Polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor
The structure was published by Beria, I., Ballinari, D., Bertrand, J.A., et al., Storici, P., Volpi, D., and Valsasina, B., in 2010 in a paper entitled "Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2009.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Serine/threonine-protein kinase PLK1. This molecule has the UniProt identifier P53350 (PLK1_HUMAN). The sample contained 311 residues which is < 90% of the natural sequence. Out of 311 residues 290 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms homodimers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: