3kac Summary

pdbe.org/3kac
spacer

Structure-guided design of alpha-amino acid-derived Pin1 inhibitors

The structure was published by Potter, A.J., Ray, S., Gueritz, L., et al., Murray, J.B., Richardson, C.M., and Moore, J.D., in 2010 in a paper entitled "Structure-guided design of alpha-amino acid-derived Pin1 inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Q13526 (45-163) (PIN1_HUMAN)search Homo sapienssearch 97% 123 93%
B Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Q13526 (45-163) (PIN1_HUMAN)search Homo sapienssearch 97% 123 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q13526 (45 - 163) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q13526) Chitinase A; domain 3search PF00639: PPIC-type PPIASE domainsearch

Chain ID Molecular function (GO)
A, B (Q13526) isomerase activitysearch

Chain InterPro annotation
A, B Peptidyl-prolyl cis-trans isomerase, PpiC-typesearch Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved sitesearch