3k7k Summary

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Crystal structure of the complex between Carbonic Anhydrase II and anions

The structure was published by Temperini, C., Scozzafava, A., and Supuran, C.T., in 2010 in a paper entitled "Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II-trithiocarbonate adduct-An inhibitor mimicking the sulfonamide and urea binding to the enzyme" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) cytoplasmsearch microvillussearch apical part of cellsearch plasma membranesearch cytosolsearch membranesearch extracellular vesicular exosomesearch basolateral plasma membranesearch axonsearch myelin sheathsearch extracellular spacesearch response to estrogensearch positive regulation of cellular pH reductionsearch positive regulation of bone resorptionsearch kidney developmentsearch positive regulation of synaptic transmission, GABAergicsearch response to zinc ionsearch positive regulation of dipeptide transmembrane transportsearch one-carbon metabolic processsearch odontogenesis of dentin-containing toothsearch bicarbonate transportsearch positive regulation of osteoclast differentiationsearch response to pHsearch small molecule metabolic processsearch secretionsearch regulation of anion transportsearch response to steroid hormonesearch morphogenesis of an epitheliumsearch regulation of intracellular pHsearch angiotensin-activated signaling pathwaysearch regulation of chloride transportsearch response to organic substancesearch metal ion bindingsearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch lyase activitysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch