Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
alpha-thrombin complex (preferred)
PDBe Complex ID:
PDB-CPX-133055 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Activation peptide fragment 2
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 12.62 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains: Kringle domain
Structure domains: Plasminogen Kringle 4
Length: 116 amino acids
Theoretical weight: 12.62 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P00734 (Residues: 199-314; Coverage: 19%)
Sequence domains: Kringle domain
Structure domains: Plasminogen Kringle 4
Thrombin heavy chain
Molecule details ›
Chain: B
Length: 308 amino acids
Theoretical weight: 35.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains: Trypsin-like serine proteases
Length: 308 amino acids
Theoretical weight: 35.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P00734 (Residues: 315-622; Coverage: 52%)
Sequence domains:
Structure domains: Trypsin-like serine proteases
