3k34 Summary


Human carbonic anhydrase II with a sulfonamide inhibitor

The structure was published by Behnke, C.A., Le Trong, I., Godden, J.W., et al., Teller, D.C., Bajorath, J., and Stenkamp, R.E., in 2010 in a paper entitled "Atomic resolution studies of carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 0.9 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) zinc ion bindingsearch metal ion bindingsearch carbonate dehydratase activitysearch protein bindingsearch lyase activitysearch morphogenesis of an epitheliumsearch one-carbon metabolic processsearch secretionsearch response to zinc ionsearch bicarbonate transportsearch response to stresssearch positive regulation of osteoclast differentiationsearch small molecule metabolic processsearch positive regulation of bone resorptionsearch regulation of intracellular pHsearch response to pHsearch regulation of anion transportsearch response to estrogen stimulussearch response to steroid hormone stimulussearch positive regulation of dipeptide transmembrane transportsearch kidney developmentsearch response to organic substancesearch odontogenesis of dentin-containing toothsearch carbon dioxide transportsearch angiotensin-mediated signaling pathwaysearch positive regulation of cellular pH reductionsearch cytoplasmsearch cytosolsearch apical part of cellsearch plasma membranesearch axonsearch basolateral plasma membranesearch extracellular spacesearch microvillussearch membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2/13search Carbonic anhydrase, alpha-classsearch