3k2m Summary

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Crystal Structure of Monobody HA4/Abl1 SH2 Domain Complex

The structure was published by Wojcik, J., Hantschel, O., Grebien, F., et al., Koide, A., Superti-Furga, G., and Koide, S., in 2010 in a paper entitled "A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.75 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Proto-oncogene tyrosine-protein kinase ABL1 and Monobody HA4.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase ABL1 P00519 (121-232) (ABL1_HUMAN)search Homo sapienssearch < 90% 112 89%
B Proto-oncogene tyrosine-protein kinase ABL1 P00519 (121-232) (ABL1_HUMAN)search Homo sapienssearch < 90% 112 89%
C Monobody HA4 Not available
Homo sapienssearch Not available 101 100%
D Monobody HA4 Not available
Homo sapienssearch Not available 101 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00519 (121 - 232) Proto-oncogene tyrosine-protein kinase ABL1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B SHC Adaptor Proteinsearch SH2 domainsearch
C, D Immunoglobulinssearch
Chain InterPro annotation
A, B SH2 domainsearch
C, D Fibronectin type IIIsearch Immunoglobulin-like foldsearch