3k2f Summary


Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma

The structure was published by Steele, R.M., Benedini, F., Biondi, S., et al., Cecchi, A., Temperini, C., and Supuran, C.T., in 2009 in a paper entitled "Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.98 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch lyase activitysearch axonsearch cytoplasmsearch myelin sheathsearch extracellular vesicular exosomesearch cytosolsearch apical part of cellsearch plasma membranesearch basolateral plasma membranesearch microvillussearch extracellular spacesearch membranesearch cellular response to fluid shear stresssearch regulation of chloride transportsearch bicarbonate transportsearch response to estrogensearch kidney developmentsearch morphogenesis of an epitheliumsearch regulation of intracellular pHsearch angiotensin-activated signaling pathwaysearch secretionsearch response to organic substancesearch one-carbon metabolic processsearch response to steroid hormonesearch positive regulation of bone resorptionsearch regulation of anion transportsearch response to zinc ionsearch odontogenesis of dentin-containing toothsearch positive regulation of osteoclast differentiationsearch positive regulation of synaptic transmission, GABAergicsearch small molecule metabolic processsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of cellular pH reductionsearch response to pHsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch