› 3jzc

X-ray diffraction
2.5Å resolution

Crystal Structure of TR-beta bound to the selective thyromimetic TRIAC

Released:
DOI: 10.2210/pdb3jzc/pdb
PDB entry 3jzc coloured by chain, front view.
PDB entry 3jzc coloured by chain, side view.
PDB entry 3jzc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Gaining ligand selectivity in thyroid hormone receptors via entropy.
Martínez L, Nascimento AS, Nunes FM, Phillips K, Aparicio R, Dias SM, Figueira AC, Lin JH, Nguyen P, Apriletti JW, Neves FA, Baxter JD, Webb P, Skaf MS, Polikarpov I
Proc Natl Acad Sci U S A 106 20717-22 (2009)
PMID: 19926848

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145480 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thyroid hormone receptor beta Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 30.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10828 (Residues: 202-461; Coverage: 56%)
Gene names: ERBA2, NR1A2, THR1, THRB
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 4HY 1 x 4HY
1 modified residue:
Ligand CAS 4 x CAS

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU ULTRAX 18
Spacegroup: P3121
Unit cell:
a: 68.781Å b: 68.781Å c: 131.013Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.198 0.246
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones.
Mondal et al. (2016)
11 more

1 mention without citation

Gaining ligand selectivity in thyroid hormone receptors via entropy.
Martínez et al. (2009)