3jvt Summary

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Calcium-bound Scallop Myosin Regulatory Domain (Lever Arm) with Reconstituted Complete Light Chains

The structure was published by Himmel, D.M., Mui, S., O'Neall-Hennessey, E., Szent-Gyorgyi, A.G., and Cohen, C., in 2009 in a paper entitled "The on-off switch in regulated myosins: different triggers but related mechanisms." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Myosin heavy chain, striated adductor muscle, Myosin regulatory light chain, striated adductor muscle, and Myosin essential light chain, striated adductor muscle.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Myosin heavy chain, striated adductor muscle P24733 (773-837) (MYS_ARGIR)search Argopecten irradianssearch < 90% 65 96%
B Myosin regulatory light chain, striated adductor muscle P13543 (2-157) (MLR_ARGIR)search Argopecten irradianssearch 92% 156 100%
C Myosin essential light chain, striated adductor muscle P07291 (2-157) (MLE_ARGIR)search Argopecten irradianssearch 95% 156 100%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P24733 (773 - 837) Myosin heavy chain, striated adductor muscle Argopecten irradians
P13543 (2 - 157) Myosin regulatory light chain, striated adductor muscle Argopecten irradians
P07291 (2 - 157) Myosin essential light chain, striated adductor muscle Argopecten irradians

Chain Structural classification (CATH) Sequence family (Pfam)
A IQ calmodulin-binding motifsearch
B (P13543) EF-handsearch PF00036: EF handsearch
C (P07291) EF-handsearch

Chain ID Molecular function (GO) Cellular component (GO)
B (P13543) calcium ion bindingsearch metal ion bindingsearch myosin complexsearch
C (P07291) calcium ion bindingsearch myosin complexsearch

Chain InterPro annotation
A IQ motif, EF-hand binding sitesearch Myosin-like IQ motif-containing domainsearch P-loop containing nucleoside triphosphate hydrolasesearch
B EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
C EF-hand domainsearch EF-hand domain pairsearch