3iyn Summary

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3.6-Angstrom cryoEM structure of human adenovirus type 5

The structure was published by Liu, H., Jin, L., Koh, S.B., et al., Schein, S., Wu, L., and Zhou, Z.H., in 2010 in a paper entitled "Atomic structure of human adenovirus by cryo-EM reveals interactions among protein networks" (abstract).

The structure was determined using Electron microscopy at a resolution of 3.6 Å and deposited in 2010.

The experimental data on which the structure is based was deposited separately in EMDB as entry 5172.

This entry contains 20 copies of 5 unique biopolymers (complete list).

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hexon protein P04133 (1-952) (CAPSH_ADE05)search Human adenovirus 5search 100% 952 96%
B Hexon protein P04133 (1-952) (CAPSH_ADE05)search Human adenovirus 5search 100% 952 96%
C Hexon protein P04133 (1-952) (CAPSH_ADE05)search Human adenovirus 5search 100% 952 96%
D Hexon protein P04133 (1-952) (CAPSH_ADE05)search Human adenovirus 5search 100% 952 96%
E Hexon protein P04133 (1-952) (CAPSH_ADE05)search Human adenovirus 5search 100% 952 96%
F Hexon protein P04133 (1-952) (CAPSH_ADE05)search Human adenovirus 5search 100% 952 96%
G Hexon protein P04133 (1-952) (CAPSH_ADE05)search Human adenovirus 5search 100% 952 96%
H Hexon protein P04133 (1-952) (CAPSH_ADE05)search Human adenovirus 5search 100% 952 96%
I Hexon protein P04133 (1-952) (CAPSH_ADE05)search Human adenovirus 5search 100% 952 96%
J Hexon protein P04133 (1-952) (CAPSH_ADE05)search Human adenovirus 5search 100% 952 96%
K Hexon protein P04133 (1-952) (CAPSH_ADE05)search Human adenovirus 5search 100% 952 96%
L Hexon protein P04133 (1-952) (CAPSH_ADE05)search Human adenovirus 5search 100% 952 96%
M Penton base protein P12538 (1-571) (CAPSP_ADE05)search Human adenovirus 5search 100% 571 79%
N Peripentonal hexon-associated protein P12537 (1-585) (CAP3_ADE05)search Human adenovirus 5search 100% 585 48%
O Hexon-associated protein P24936 (1-227) (CAP8_ADE05)search Human adenovirus 5search 100% 227 77%
P Hexon-associated protein P24936 (1-227) (CAP8_ADE05)search Human adenovirus 5search 100% 227 77%
Q Hexon-associated protein P03281 (1-140) (CAP9_ADE05)search Human adenovirus 5search 100% 140 91%
R Hexon-associated protein P03281 (1-140) (CAP9_ADE05)search Human adenovirus 5search 100% 140 91%
S Hexon-associated protein P03281 (1-140) (CAP9_ADE05)search Human adenovirus 5search 100% 140 91%
T Hexon-associated protein P03281 (1-140) (CAP9_ADE05)search Human adenovirus 5search 100% 140 91%


This entry contains 5 unique UniProt proteins:

UniProt accession Name Organism PDB
P04133 (1 - 952) Hexon protein Human adenovirus 5
P12538 (1 - 571) Penton base protein Human adenovirus 5
P12537 (1 - 585) Peripentonal hexon-associated protein Human adenovirus 5
P24936 (1 - 227) Hexon-associated protein Human adenovirus 5
P03281 (1 - 140) Hexon-associated protein Human adenovirus 5

Chain Sequence family (Pfam)
A, B, C, D, E, F, G, H, I, J, K, L (P04133) PF01065: Hexon, adenovirus major coat protein, N-terminal domainsearch, PF03678: Hexon, adenovirus major coat protein, C-terminal domainsearch
M (P12538) PF01686: Adenovirus penton base proteinsearch
N (P12537) PF02455: Hexon-associated protein (IIIa)search
O, P (P24936) PF01310: Adenovirus hexon associated protein, protein VIIIsearch
Q, R, S, T (P03281) PF03955: Adenovirus hexon-associated protein (IX)search

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, C, D, E, F, G, H, I, J, K, L (P04133) structural molecule activitysearch viral capsidsearch T=25 icosahedral viral capsidsearch virionsearch host cell nucleussearch transport of viral material towards nucleussearch viral processsearch microtubule-dependent intracellular transport of viral material towards nucleussearch viral entry into host cellsearch
M (P12538) structural molecule activitysearch T=25 icosahedral viral capsidsearch virionsearch host cell nucleussearch viral capsidsearch endocytosis involved in viral entry into host cellsearch virion attachment to host cellsearch viral entry into host cellsearch clathrin-mediated endocytosis of virus by host cellsearch viral processsearch
N (P12537) virionsearch viral capsidsearch host cell nucleussearch viral release from host cellsearch
O, P (P24936) hexon bindingsearch host cell nucleussearch virionsearch viral capsidsearch
Q, R, S, T (P03281) hexon bindingsearch virionsearch host cell nucleussearch viral capsidsearch viral processsearch viral entry into host cellsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H, I, J, K, L Adenovirus Pll, hexon, N-terminalsearch Adenovirus Pll, hexon, C-terminalsearch Adenovirus Pll, hexon, subdomain 3search Hexon coat protein, subdomain 4search Group II dsDNA virus coat/capsid proteinsearch
M Adenovirus penton base proteinsearch
N Hexon-associated proteinsearch
O, P Adenovirus hexon associated protein VIIIsearch
Q, R, S, T Hexon-associated protein IXsearch