3iw6 Summary


Human p38 MAP Kinase in Complex with a Benzylpiperazin-Pyrrol

The structure was published by Simard, J.R., Gruetter, C., Pawar, V., et al., Kluter, S., Ottmann, C., and Rauh, D., in 2009 in a paper entitled "High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 335 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q16539) protein serine/threonine kinase activitysearch protein bindingsearch NFAT protein bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch ATP bindingsearch MAP kinase activitysearch kinase activitysearch nucleotide bindingsearch transferase activitysearch MAP kinase kinase activitysearch nucleussearch cytoplasmsearch mitochondrionsearch nucleoplasmsearch cytosolsearch cellsearch extracellular vesicular exosomesearch spindle polesearch positive regulation of reactive oxygen species metabolic processsearch muscle cell differentiationsearch positive regulation of myoblast fusionsearch toll-like receptor 3 signaling pathwaysearch signal transduction in response to DNA damagesearch positive regulation of myoblast differentiationsearch activation of MAPK activitysearch toll-like receptor 2 signaling pathwaysearch chemotaxissearch striated muscle cell differentiationsearch fatty acid oxidationsearch toll-like receptor 4 signaling pathwaysearch blood coagulationsearch peptidyl-serine phosphorylationsearch protein phosphorylationsearch RNA metabolic processsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch toll-like receptor signaling pathwaysearch positive regulation of muscle cell differentiationsearch Ras protein signal transductionsearch MyD88-dependent toll-like receptor signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch platelet activationsearch positive regulation of myotube differentiationsearch osteoclast differentiationsearch vascular endothelial growth factor receptor signaling pathwaysearch positive regulation of erythrocyte differentiationsearch positive regulation of blood vessel endothelial cell migrationsearch toll-like receptor 9 signaling pathwaysearch positive regulation of protein import into nucleussearch positive regulation of transcription from RNA polymerase II promotersearch TRIF-dependent toll-like receptor signaling pathwaysearch regulation of transcription, DNA-templatedsearch response to muramyl dipeptidesearch regulation of transcription from RNA polymerase II promotersearch apoptotic processsearch stress-activated MAPK cascadesearch cellular component movementsearch 3'-UTR-mediated mRNA stabilizationsearch glucose metabolic processsearch toll-like receptor 5 signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch cell morphogenesissearch skeletal muscle tissue developmentsearch mRNA metabolic processsearch stress-induced premature senescencesearch cellular response to lipopolysaccharidesearch p38MAPK cascadesearch response to stresssearch cell surface receptor signaling pathwaysearch intracellular signal transductionsearch neurotrophin TRK receptor signaling pathwaysearch signal transductionsearch negative regulation of canonical Wnt signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch response to lipopolysaccharidesearch lipopolysaccharide-mediated signaling pathwaysearch cellular response to ionizing radiationsearch toll-like receptor 10 signaling pathwaysearch innate immune responsesearch phosphorylationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch transcription, DNA-templatedsearch cartilage condensationsearch cellular response to DNA damage stimulussearch chondrocyte differentiationsearch myoblast differentiation involved in skeletal muscle regenerationsearch angiogenesissearch DNA damage checkpointsearch gene expressionsearch cellular response to vascular endothelial growth factor stimulussearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch