3iw6 Summary


Human p38 MAP Kinase in Complex with a Benzylpiperazin-Pyrrol

The structure was published by Simard, J.R., Gruetter, C., Pawar, V., et al., Kluter, S., Ottmann, C., and Rauh, D., in 2009 in a paper entitled "High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 335 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase activitysearch protein bindingsearch kinase activitysearch protein serine/threonine kinase activitysearch NFAT protein bindingsearch nucleotide bindingsearch transferase activitysearch MAP kinase kinase activitysearch protein phosphorylationsearch vascular endothelial growth factor receptor signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch DNA damage checkpointsearch positive regulation of blood vessel endothelial cell migrationsearch Ras protein signal transductionsearch MAPK cascadesearch peptidyl-serine phosphorylationsearch cartilage condensationsearch positive regulation of myotube differentiationsearch osteoclast differentiationsearch MyD88-dependent toll-like receptor signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch platelet activationsearch toll-like receptor signaling pathwaysearch positive regulation of muscle cell differentiationsearch RNA metabolic processsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch striated muscle cell differentiationsearch regulation of transcription from RNA polymerase II promotersearch stress-activated MAPK cascadesearch cellular component movementsearch chondrocyte differentiationsearch response to stresssearch angiogenesissearch 3'-UTR-mediated mRNA stabilizationsearch response to muramyl dipeptidesearch cellular response to DNA damage stimulussearch cell morphogenesissearch phosphorylationsearch TRIF-dependent toll-like receptor signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch cell surface receptor signaling pathwaysearch signal transductionsearch intracellular signal transductionsearch toll-like receptor 10 signaling pathwaysearch innate immune responsesearch fatty acid oxidationsearch negative regulation of canonical Wnt signaling pathwaysearch cellular response to lipopolysaccharidesearch lipopolysaccharide-mediated signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch regulation of sequence-specific DNA binding transcription factor activitysearch p38MAPK cascadesearch regulation of transcription, DNA-templatedsearch positive regulation of erythrocyte differentiationsearch cellular response to ionizing radiationsearch mRNA metabolic processsearch glucose metabolic processsearch stress-induced premature senescencesearch toll-like receptor 3 signaling pathwaysearch blood coagulationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch skeletal muscle tissue developmentsearch apoptotic processsearch positive regulation of reactive oxygen species metabolic processsearch activation of MAPK activitysearch toll-like receptor 2 signaling pathwaysearch chemotaxissearch muscle cell differentiationsearch response to lipopolysaccharidesearch positive regulation of myoblast fusionsearch positive regulation of protein import into nucleussearch positive regulation of myoblast differentiationsearch transcription, DNA-templatedsearch signal transduction in response to DNA damagesearch cellular response to vascular endothelial growth factor stimulussearch gene expressionsearch nucleussearch extracellular vesicular exosomesearch nucleoplasmsearch cytosolsearch cytoplasmsearch mitochondrionsearch cellsearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch