› 3iw4

X-ray diffraction
2.8Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147902 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein kinase C alpha type Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 360 amino acids
Theoretical weight: 41.57 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P17252 (Residues: 320-672; Coverage: 53%)
Gene names: PKCA, PRKACA, PRKCA
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand LW4 3 x LW4
2 modified residues:
Ligand TPO 3 x TPO
Ligand SEP 3 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 43.868Å b: 100.669Å c: 251.335Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.192 0.277
Expression system: Spodoptera frugiperda

Quick links

Citations

16 review citations

Natural product and natural product derived drugs in clinical trials.
Butler et al. (2014)
15 more

39 mentions without citation

Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores.
Gógl et al. (2019)
38 more