3iw4 Summary


Crystal structure of PKC alpha in complex with NVP-AEB071

The structure was published by Wagner, J., von Matt, P., Sedrani, R., et al., Evenou, J.P., Zenke, G., and Cottens, S., in 2009 in a paper entitled "Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Protein kinase C alpha type.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein kinase C alpha type Not available
Homo sapienssearch < 90% 360 92%
B Protein kinase C alpha type P17252 (320-672) (KPCA_HUMAN)search Homo sapienssearch < 90% 360 92%
C Protein kinase C alpha type P17252 (320-672) (KPCA_HUMAN)search Homo sapienssearch < 90% 360 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P17252 (320 - 672) Protein kinase C alpha type Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, Protein kinase C terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B, C (P17252) protein phosphorylationsearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein kinase activitysearch

Chain InterPro annotation
A, B, C Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Protein kinase, C-terminalsearch