3it8 Summary

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Crystal structure of TNF alpha complexed with a poxvirus MHC-related TNF binding protein

The structure was published by Yang, Z., West Jr., A.P., and Bjorkman, P.J., in in a paper entitled "Crystal structure of TNFa complexed with a poxvirus MHC-related TNF binding protein" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Tumor necrosis factor and 2L protein.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tumor necrosis factor P01375 (82-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 161 94%
B Tumor necrosis factor P01375 (82-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 161 94%
C Tumor necrosis factor P01375 (82-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 161 94%
G Tumor necrosis factor P01375 (82-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 161 94%
H Tumor necrosis factor P01375 (82-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 161 94%
I Tumor necrosis factor P01375 (82-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 161 94%
D 2L protein Q9DHW0 (17-332) (Q9DHW0_YLDV)search Yaba-like disease virussearch 98% 324 92%
E 2L protein Q9DHW0 (17-332) (Q9DHW0_YLDV)search Yaba-like disease virussearch 98% 324 92%
F 2L protein Q9DHW0 (17-332) (Q9DHW0_YLDV)search Yaba-like disease virussearch 98% 324 92%
J 2L protein Q9DHW0 (17-332) (Q9DHW0_YLDV)search Yaba-like disease virussearch 98% 324 92%
K 2L protein Q9DHW0 (17-332) (Q9DHW0_YLDV)search Yaba-like disease virussearch 98% 324 92%
L 2L protein Q9DHW0 (17-332) (Q9DHW0_YLDV)search Yaba-like disease virussearch 98% 324 92%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01375 (82 - 233) Tumor necrosis factor Homo sapiens
Q9DHW0 (17 - 332) 2L protein Yaba-like disease virus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, G, H, I Jelly Rollssearch TNF(Tumour Necrosis Factor) familysearch
D, E, F, J, K, L

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B, C, G, H, I (P01375) immune responsesearch membranesearch tumor necrosis factor receptor bindingsearch

Chain InterPro annotation
A, B, C, G, H, I Tumour necrosis factor alphasearch Tumour necrosis factor domainsearch Tumour necrosis factorsearch Tumour necrosis factor-like domainsearch Tumour necrosis factor, conserved sitesearch
D, E, F, J, K, L Immunoglobulin-like domainsearch Immunoglobulin-like foldsearch