3ipu Summary


X-ray structure of benzisoxazole urea synthetic agonist bound to the LXR-alpha

The structure was published by Fradera, X., Vu, D., Nimz, O., et al., Bennett, D.J., McGuire, R., and Uitdehaag, J.C., in 2010 in a paper entitled "X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Oxysterols receptor LXR-alpha and Nuclear receptor coactivator 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Oxysterols receptor LXR-alpha Q13133 (182-447) (NR1H3_HUMAN)search Homo sapienssearch < 90% 283 84%
B Oxysterols receptor LXR-alpha Q13133 (182-447) (NR1H3_HUMAN)search Homo sapienssearch < 90% 283 84%
C Nuclear receptor coactivator 1 Q15788 (676-700) (NCOA1_HUMAN)search Homo sapienssearch < 90% 25 60%
D Nuclear receptor coactivator 1 Q15788 (676-700) (NCOA1_HUMAN)search Homo sapienssearch < 90% 25 60%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q13133 (182 - 447) Oxysterols receptor LXR-alpha Homo sapiens
Q15788 (676 - 700) Nuclear receptor coactivator 1

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
C, D Steroid receptor coactivatorsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (Q13133) nucleussearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch Liver X receptorsearch
C, D Nuclear receptor coactivator Src-1search Steroid receptor coactivatorsearch Nuclear receptor coactivatorsearch Nuclear receptor coactivator 1search