› › Function and Biology

X-ray structure of benzisoxazole synthetic agonist bound to the LXR-alpha

Source organism: Homo sapiens
Biochemical function: nuclear receptor activity
Biological process: lipid metabolic process
Cellular component: not assigned

Quick links

EC 2.3.1.48: Histone acetyltransferase

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[protein]-L-lysine acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:histone acetyltransferase
  • Histone acetokinase
  • Histone acetylase
  • Histone transacetylase
  • Lysine acetyltransferase
  • Nucleosome-histone acetyltransferase
  • Protein lysine acetyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF08832
Domain description: Steroid receptor coactivator
Occurring in:
  1. Nuclear receptor coactivator 1
The deposited structure of PDB entry 3ips contains 2 copies of Pfam domain PF08832 (Steroid receptor coactivator) in Nuclear receptor coactivator 1. Showing 1 copy in chain C.

PF00104
Domain description: Ligand-binding domain of nuclear hormone receptor
Occurring in:
  1. Oxysterols receptor LXR-alpha
The deposited structure of PDB entry 3ips contains 2 copies of Pfam domain PF00104 (Ligand-binding domain of nuclear hormone receptor) in Oxysterols receptor LXR-alpha. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001723
Domain description: Nuclear hormone receptor
Occurring in:
  1. Oxysterols receptor LXR-alpha
IPR023257
Domain description: Liver X receptor
Occurring in:
  1. Oxysterols receptor LXR-alpha
IPR000536
Domain description: Nuclear hormone receptor, ligand-binding domain
Occurring in:
  1. Oxysterols receptor LXR-alpha
IPR035500
Domain description: Nuclear hormone receptor-like domain superfamily
Occurring in:
  1. Oxysterols receptor LXR-alpha
IPR014935
Domain description: Nuclear receptor coactivator, receptor-binding domain
Occurring in:
  1. Nuclear receptor coactivator 1

Structure domain

CATH CATH domain
1.10.565.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Retinoid X Receptor
Homology: Retinoid X Receptor
Occurring in:
  1. Oxysterols receptor LXR-alpha
The deposited structure of PDB entry 3ips contains 2 copies of CATH domain 1.10.565.10 (Retinoid X Receptor) in Oxysterols receptor LXR-alpha. Showing 1 copy in chain B.

Quick links