PDK-1 in complex with the inhibitor Compound-8i
The structure was published by Nittoli, T., Dushin, R.G., Ingalls, C., et al., Arndt, K., Guo, B., and Wissner, A., in 2010 in a paper entitled "The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1)." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2009.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of 3-phosphoinositide-dependent protein kinase 1. This molecule has the UniProt identifier O15530 (PDPK1_HUMAN). The sample contained 312 residues which is < 90% of the natural sequence. Out of 312 residues 275 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: