2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2
The structure was published by Ledeboer, M.W., Pierce, A.C., Duffy, J.P., et al., Zessis, R., Pazhanisamy, S., and Bennani, Y.L., in 2009 in a paper entitled "2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2009.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Tyrosine-protein kinase JAK2. This molecule has the UniProt identifier O60674 (JAK2_HUMAN). The sample contained 313 residues which is < 90% of the natural sequence. Out of 313 residues 287 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: