3io7 Summary

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2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2

The structure was published by Ledeboer, M.W., Pierce, A.C., Duffy, J.P., et al., Zessis, R., Pazhanisamy, S., and Bennani, Y.L., in 2009 in a paper entitled "2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Tyrosine-protein kinase JAK2. This molecule has the UniProt identifier O60674 (JAK2_HUMAN)search. The sample contained 313 residues which is < 90% of the natural sequence. Out of 313 residues 284 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase JAK2 O60674 (842-1132) (JAK2_HUMAN)search Homo sapienssearch < 90% 313 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O60674 (842 - 1132) Tyrosine-protein kinase JAK2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (O60674) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch