3imx Summary


Crystal Structure of human glucokinase in complex with a synthetic activator

The structure was published by Bebernitz, G.R., Beaulieu, V., Dale, B.A., et al., Taslimi, P.M., Vash, B., and Caplan, S.L., in 2009 in a paper entitled "Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 455 residues which is 97% of the natural sequence. Out of 455 residues 447 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 455 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) Glucokinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P35557) Hexokinase; domain 1search, Nucleotidyltransferase; domain 5search PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P35557) regulation of glucose transportsearch cellular response to insulin stimulussearch second-messenger-mediated signalingsearch cellular response to leptin stimulussearch glycolytic processsearch calcium ion importsearch regulation of potassium ion transportsearch carbohydrate phosphorylationsearch cellular glucose homeostasissearch positive regulation of cytosolic calcium ion concentrationsearch NADP metabolic processsearch carbohydrate metabolic processsearch response to glucosesearch glucose metabolic processsearch positive regulation of insulin secretionsearch positive regulation of glycogen biosynthetic processsearch cellular response to glucose starvationsearch positive regulation of phosphorylationsearch glucose homeostasissearch regulation of glycolytic processsearch glycogen biosynthetic processsearch hexose transportsearch glucose transportsearch phosphorylationsearch regulation of insulin secretionsearch detection of glucosesearch metabolic processsearch endocrine pancreas developmentsearch glucose 6-phosphate metabolic processsearch transmembrane transportsearch negative regulation of gluconeogenesissearch negative regulation of epinephrine secretionsearch positive regulation of glycolytic processsearch small molecule metabolic processsearch fructose 2,6-bisphosphate metabolic processsearch mitochondrionsearch nucleussearch cytoplasmsearch nucleoplasmsearch cytosolsearch secretory granulesearch cell cortexsearch ATP bindingsearch protein bindingsearch phosphotransferase activity, alcohol group as acceptorsearch hexokinase activitysearch nucleotide bindingsearch magnesium ion bindingsearch ADP bindingsearch glucokinase activitysearch glucose bindingsearch fructokinase activitysearch kinase activitysearch protein phosphatase bindingsearch mannokinase activitysearch catalytic activitysearch transferase activitysearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch